Antiatheroscleroic and antithrombotic 2-amino-6-phenyl-4H-pyran-

Details Antiatheroscleroic and antithrombotic 2-amino-6-phenyl-4H-pyran- Antiatheroscleroic and antithrombotic 2-amino-6-phenyl-4H-pyran-

1993-04-09

1994-04-12

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142315, 514277, 514311, 514397, 514406, 514824, 544121, A61K 3135, A61K 31535, A61K 31435, A61K 31415

Patent

active

053026136

ABSTRACT:
This invention relates to compounds of Formula I ##STR1## which are useful as antiatherosclerotic agents and inhibitors of cell proliferation for the treatment of proliferative diseases. In addition, various compounds of Formula I are useful inhibitors of platelet aggregation.

REFERENCES:
patent: 3029256 (1962-04-01), Cook
patent: 3419555 (1968-12-01), Jenkins
patent: 3468915 (1969-09-01), Tate
Capuano, L. et al., "Reactions of 2-Diazo-1,3-diketones with Enamines and Ketene-N,O-Acetals, II," Chem. Ber. 109:3497-3504 (1976).
Eaton, R. P., J. Chron. Dis., 31, pp. 131-135 (1978).
Haust, M. D., Adv. Exp. Med. Biol., 43, pp. 35-57 (1974).
Schurr, P. E., et al., Adv. Exp. Med. Biol., 67, pp. 215-229 (1975).
Day, C. E., et al., Laboratory Animal Science, 27, pp. 817-821 (1977).
Chem. Ber., 109(11), pp. 3497-3504 (1976).

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