Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1985-09-19
1987-03-03
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514346, 514344, 514348, 514347, 514349, 514352, 546276, 546287, 546288, 546289, 546291, 546292, 546293, 546294, 546295, 546296, 546297, 546305, 546307, 546308, 546309, 546310, 546312, C07D21374, C07D21384, C07D21379, A61K 3144
Patent
active
046475699
ABSTRACT:
Pyridylaminoethene derivatives of the formula: ##STR1## wherein R.sup.1 is pyridyl, unsubstituted or substituted by one or more substituents R.sup.4 selected from halogen, amino, carboxy, cyano nitro, hydroxy, formyl, trifluoromethyl, aryl, aryloxy, arylthio, benzyloxycarbonylamino, sulphamoyl, tetrazol-5-yl, carbamoyl, thiocarbamoyl, arylcarbamoyl, aroyl, alkyl, alkoxy, alkylthio, alkylsulphonyl, alkylamino, alkylsulphamoyl, arylalkyl, alkanoyl, alkoxycarbonyl, alkoxycarbonylamino, alkylcarbamoyl, alkanoylamino, N-benzyloxycarbonyl-N-alkylamino, or dialkylsulphamoyl, dialkylamino or dialkylcarbamoyl, wherein the alkyl groups may together form a ring, and R.sup.2 and R.sup.3 each represents phenyl, unsubstituted or substituted by one or more substituents R.sup.4 as hereinbefore defined, possess antiarthritic properties.
REFERENCES:
patent: 4013656 (1977-03-01), Ackermann et al.
Golds, et al. Arthritis and Rheumatism, vol. 26, No. 1 (Jan. 1983), pp. 15-21.
Janossy, G. et al. The Lancet, Oct. 17, 1981, pp. 839-842.
Baker, D. G. et al. Arthritis and Rheumatism, vol. 26, No. 1 (Jan. 1983), pp. 8-14.
Collins Raymond F.
Knowles Philip
Saunders Libert C.
Tierney Francis J.
Warne Peter J.
Bjorkman Dale A.
Jiles Henry R.
May & Baker Limited
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