Antiarteriosclerotic substituted benzimidazol-2-yl-and 3H-imidaz

Details Antiarteriosclerotic substituted benzimidazol-2-yl-and 3H-imidaz Antiarteriosclerotic substituted benzimidazol-2-yl-and 3H-imidaz

1986-10-31

1987-12-22

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514394, 546118, 548333, 548334, A61K 3144, C07D47104, C07D48704

Patent

active

047147628

ABSTRACT:
Novel substituted benzimidazol-2-yl-phenoxyalkanoic acids, salts and esters thereof and 3H-imidazo[4,5-b]pyridin-2-yl phenoxy-alkanoic acid, salts, and esters which are useful as antiarteriosclerotic agents are disclosed. The compounds elevate the high density lipoprotein fraction of cholesterol and also lower the low density lipoprotein fraction of cholesterol. Methods for preparing and using the compounds are included.

REFERENCES:
patent: 3674836 (1972-07-01), Creger
patent: 3707566 (1972-12-01), Creger et al.
Gordon, T. et al., High Density Lipoprotein as a Protective Factor Against Coronary Heart Disease, May 1977, Amn. J. Med., 62, pp. 707-714, JAMA 251, pp. 361 and 365, 1984.

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