Antiarrhythmic tetrahydronaphthalene derivatives

Details Antiarrhythmic tetrahydronaphthalene derivatives Antiarrhythmic tetrahydronaphthalene derivatives

1981-08-06

1982-09-21

Raymond, Richard

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

260239BC, 260239BF, 2602457, 260330, 544 584, 544357, 546187, 546189, 548200, 548215, 548300, 548518, 564156, 549433, C07C10329, C07C10385, C07D26530

Patent

active

043508120

ABSTRACT:
Compounds are provided having the structure ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and are hydrogen, lower alkyl, lower alkenyl, or hydroxylower alkyl, or R.sup.1 and R.sup.2 together with the nitrogen atom to which they are attached also form a heterocyclic radical which may contain another heteroatom, namely nitrogen, oxygen or sulfur; R.sup.3 and R.sup.4 may be the same or different and are hydrogen or lower alkyl. These compounds are useful in the treatment of arrhythmia.
In addition, novel intermediates are provided having the structure ##STR2## wherein R is hydrogen, benzyl or ##STR3## These intermediates are also useful in treating acute myocardial infarction.

REFERENCES:
Condon et al., J. Med. Soc., vol. 21 (1978), pp. 913-922.

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