Antiarrhythmic piperidin-1-yl-2,2-dialkylpropanone arylsulfonami

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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Details

514331, 546225, 546232, 546235, A61K 31445, C07D21132

Patent

active

055412017

ABSTRACT:
The invention is directed to a new class of antiarrhythmic agents of the formula: ##STR1## in which R is represented by hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, CF.sub.3, SR.sub.1, NHC(O)R.sub.2, NH.sub.2, or OH; R.sub.1 is hydrogen or C.sub.1-4 alkyl; R.sub.2 is C.sub.1-4 alkyl; X is represented by CO or CHOH; R.sub.3 and R.sub.4 are each independently represented by methyl, ethyl, n-propyl, or R.sub.3 and R.sub.4 together with the carbon atom to which they each are attached form a C.sub.5 or C.sub.6 cycloalkyl; and Alk is a C.sub.1-4 alkyl; or a pharmaceutically acceptable addition salt thereof.

REFERENCES:
patent: 4876262 (1989-10-01), Oinuma
patent: 4996215 (1991-02-01), Oinuma
patent: 5118689 (1992-06-01), Oinuma
patent: 5179095 (1993-01-01), Oinuma

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