Antiarrhythmic peptides

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Details

C514S016700, C514S017400, C514S018700

Reexamination Certificate

active

07737113

ABSTRACT:
Disclosed are novel peptides including antiarrhythmic peptides that have improved stability. Further disclosed are compositions that include such peptides and methods of using the compositions particularly as medicaments.

REFERENCES:
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patent: WO 96/21674 (1996-07-01), None
patent: WO 01/62775 (2001-08-01), None
patent: WO 02/077017 (2002-10-01), None
Lazar et al., Molecular and Cellular Biology, 1988, vol. 8, pp. 1247-1252.
Y. Kohama, et al. “Effect of N-3-(4-Hydroxyphenyl) propionyl Pro-Pro-Gly-Ala-Gly on Calcium-Induced Arrhythmias”, Chemical & Pharmaceutical Bulletin, vol. 36, No. 11, 1988, pp. 4597-4599.
S. Dhein, et al. “Therapeutic Potential of Antiarrhythmic Peptides”, Drugs, vol. 49, No. 6, 1995, pp. 851-855.
B. Kundu “Synthesis, conformational features and biological activity of Pro-3 antiarrhythmic peptide”, Collection of Czechoslovak Chemical Communications, vol. 54, No. 3, 1989, pp. 760-771.
B. Weinstein “Chemistry and Biochemistry of Amino Acids, Peptides and Proteins” 1982, Marcel Dekker Inc., New York and Basel, p. 357.
Chorev et al., “Recent developments in retro peptides and proteins—an ongoing topochemical exploration”TIBTECH13:438-445, (1995).
Dhein et al,, “A new synthetic antiarrhythmic peptide reduces dispersion of epicardical activation recovery interval and diminishes alterations of epicardial activation patterns induced by regional ischemia”Naunyn-Schmiedeberg's Arch Pharmacol350:174-184, (1994).
Grover et al., “Spatial structure determination of antiarrhythmic peptide using nuclear magnetic resonance spectrospcopy”Peptides19:1725-1729, (1998).
Office Action in Japanese Application No. 2001-562556 mailed Sep. 16, 2008 and English language translation.

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