Antiarrhythmic peptide from venom of spider Grammostola spatulat

Details Antiarrhythmic peptide from venom of spider Grammostola spatulat Antiarrhythmic peptide from venom of spider Grammostola spatulat

1998-01-21

1999-10-19

Tsang, Cecilia J.

Chemistry: analytical and immunological testing

Biospecific ligand binding assay

530324, 424538, G01N 33566

Patent

active

059688386

ABSTRACT:
The invention provides a novel peptide isolated from the venom of the spider Grammostola spatulata which peptide has antiarrhthymic activity. The invention also provides methods of treating arrhthymia comprising administering to a patient in need of such treatment an effective amount of the peptide. The invention further provides pharmaceutical compositions and methods of mediating hypotonic cell swelling induced calcium increase in cells.

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patent: 5196204 (1993-03-01), Jackson et al.
patent: 5281693 (1994-01-01), Jackson et al.
Lampe et al., "Isolation and Pharmacological Characterization of .omega.-Grammotoxin SIA, a Novel Peptide Inhibitor of Neuronal Voltage-Sensitive Calcium Channel Responses", Molecular Pharmacology, 44:451-460, May 18, 1993.

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