Antiarrhythmic peptide from venom of spider Grammostola spatulat

Details Antiarrhythmic peptide from venom of spider Grammostola spatulat Antiarrhythmic peptide from venom of spider Grammostola spatulat

1996-12-30

1998-05-26

Tsang, Cecilia J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

514 2, 514 12, A61K 3816, C07K 1400

Patent

active

057566631

ABSTRACT:
The invention provides a novel peptide isolated from the venom of the spider Grammostola spatulata which peptide has antiarrhthymic activity. The invention also provides methods of treating arrhthymia comprising administering to a patient in need of such treatment an effective amount of the peptide. The invention further provides pharmaceutical compositions and methods of mediating hypotonic cell swelling induced calcium increase in cells.

REFERENCES:
patent: 4925664 (1990-05-01), Jackson et al.
patent: 5064657 (1991-11-01), Jackson et al.
patent: 5122596 (1992-06-01), Phillips et al.
patent: 5196204 (1993-03-01), Jackson et al.
patent: 5281693 (1994-01-01), Jackson et al.
Lampe et al., `isolation and Pharmacological Characterization of .omega.-Grammotoxin SIA, a Novel Peptide inhibitor of Neuronal Voltage-Sensistive Calcium Channel Responses`, Molecular Pharmacology, 44:451-460, Mar. 18, 1993.

Affiliated with

Also associated with

Rating

Antiarrhythmic peptide from venom of spider Grammostola spatulat does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antiarrhythmic peptide from venom of spider Grammostola spatulat, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antiarrhythmic peptide from venom of spider Grammostola spatulat will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1961663