Antiarrhythmic methanesulfonamides

Details Antiarrhythmic methanesulfonamides Antiarrhythmic methanesulfonamides

1993-11-23

1995-04-11

O'Sullivan, Peter

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

560251, A61K 3118, A61K 3138, C07C31108, C07C 6702

Patent

active

054059976

ABSTRACT:
Methanesulfonamides are structurally depicted by Formula I' ##STR1## or its pharmacologically acceptable salts where R.sub.3 is a C.sub.1-7 alkyl substituted with C.sub.3-7 cycloalkyl, or a C.sub.1-10 alkyl substituted with one to eight fluorine atoms, one to three hydroxy, one to three C.sub.1-5 acyloxy or one to three C.sub.1-4 alkoxy substituents. These compounds are useful as Class III antiarrhythmic agents and are stable against rapid metabolism. Methods for treating cardiac arrhythmias with the compounds of Formula I' as well as compositions thereof are also described.

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Morgan, T. K., Jr. et al., "Synthesis and Class III Antiarrhythmic Activity of (Phenylbut-2-enyl)ammonium Salts. Effect of Conformation on Activity," J. Med. Chem. 29:1398-1405 (1986).

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