Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1991-09-10
1994-02-15
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514821, 564244, 564247, A61K 31155, C07C25718
Patent
active
052867528
ABSTRACT:
Novel diarylamidines, and compositions and methods for treating cardiac arrhythmias in mammals utilizing the novel and related known diarylamidines of formula I, II, III and IV ##STR1##
REFERENCES:
patent: 3862228 (1975-01-01), Rodriguez et al.
patent: 4072675 (1978-02-01), Wu et al.
Marchand-Brynaert et al. "2-amino-1-azetines, etc." J.C.S. Chem Comm. (1980) 173-4.
Meyer, H. J. et al. "Studies on Organophosphorous Compounds XIV. HMPA-Induced Rearrangements of N-Benzyl-Carboxamides into 3-Phenylpropionitriles" Bull. Soc. Chim. Belg. 84:735-739 (1975).
Winthrop, S. O. et al. "New Analeptics: 1-(Diphenylmethyl)-2-methyl-2-thiopseudourea Analogs" J. Org. Chem. 24: 1936-1939 (1959).
The Registry of Toxic Effects of Chemical Substances, Record No. 37022 (1989).
Reynaud, P. et al. "Echange d'ammoniac dans les amidines par reaction avec les amines: Mecanisme et application a la preparation d'amidines mono et N,N'-disubstituees" Bull. Soc. Chim. Fr. 1978 part II: 449-456.
Wicherink, S. C. et al. "Synthesis of Tetrasubstituted Formamininium Salts Containing Different N-Alkyl Substituents" Synthesis 1977:273-275.
Adams, R. et al. "Action of the Grignard Reagent on CN Compounds. Synthesis of Amidines from Cyanamides" J. Am. Chem. Soc. 38:2768-2772 (1916).
Kato, T. et al. "Studies on Ketene and Its Derivatives LV Reaction of Primary Amine with Ketene Acetals" Yakagaku Zasshi 93:1034-1042 (1973).
Garmaise D. L. et al. "Bacteriostats V The Preparation and Bacteriostatic Properties of Amidine Derivatives" Can. J. Chem. 39:1493-1501 (1961).
D'Ambra Thomas E.
Johnson Robert E.
Alexander Michael D.
DuPont Paul E.
O'Sullivan P.
Raymond Richard L.
Sterling Winthrop Inc.
LandOfFree
Antiarrhythmic diarylamidines does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antiarrhythmic diarylamidines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antiarrhythmic diarylamidines will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1207298