Antiarrhythmic (+,-)-cis-.alpha.-[3-(2,6-dimethyl-1-piperidinyl)

Details Antiarrhythmic (+,-)-cis-.alpha.-[3-(2,6-dimethyl-1-piperidinyl) Antiarrhythmic (+,-)-cis-.alpha.-[3-(2,6-dimethyl-1-piperidinyl)

1977-02-25

1978-09-05

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

26029351, 26029369, 2602938, 2602939, C07D21338

Patent

active

041121031

ABSTRACT:
(+,-)-cis-.alpha.[3-(2,6-Dimethyl-1-piperidinyl)propyl]-.alpha.-phenyl-2-py ridinemethanol and acid-addition salts. The compounds are pharmacological agents, especially antiarrhythmic agents. The compounds can be produced by reacting pyridyllithium with cis-.gamma.-(2,6-dimethylpiperidino)butyrophenone, or by reacting cis-1-(3-lithiopropyl)-2,6-dimethylpiperidine with 2-benzoylpyridine. Pharmaceutical compositions comprising (+,-)-cis-.alpha.-[3-(2,6-dimethyl-1-piperidinyl)propyl]-.alpha.-phenyl-2- pyridinemethanol and acid-addition salts thereof and methods for treating cardiac arrhythmia using said pharmaceutical compositions are also disclosed.

REFERENCES:
patent: 2712022 (1955-06-01), Adamson
Peterson, D. J. Am. Chem. Soc., 93(16), 4027-4031 (1971).

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