Antiarrhythmic and cardioprotective substituted -1(2H)isoquinoli

Details Antiarrhythmic and cardioprotective substituted -1(2H)isoquinoli Antiarrhythmic and cardioprotective substituted -1(2H)isoquinoli

1993-09-24

1995-05-16

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546140, 546141, 546143, 546144, 546146, 544128, 544333, 544363, 5142335, 514255, 514256, 514308, 514309, 514310, C07D21712, A61K 3147

Patent

active

054160944

ABSTRACT:
Described are guanidinocarbonyl isoquinolines of the formula I, ##STR1## wherein R(1) is hydrogen, (amino) (cyclo) (aryl)alk(en)yl (heteroaryl); R(2) is hydrogen, halogen, alkyl, or aryl; G is a radical of the formula VII: ##STR2## X(2), X(3) and X(4) are hydrogen, halogen, nitro, amino, alkyl, sulfonamide, (mono) (di) (lower alkyl) (amino), benzyloxy, hydroxy; X(1) hydrogen, oxygen, sulfur and NR(7)R(8), and their pharmaceutically acceptable salts; described is also a process for their preparation, their use as medicaments, and medicaments containing them for treating congestive heart failure, and arrhythmic conditions as well as cardioprotective agents in mammals.

REFERENCES:
patent: 3780027 (1973-12-01), Cragoe et al.
patent: 4260611 (1981-04-01), Bartmann et al.
patent: 4322418 (1982-03-01), Losel et al.
patent: 4673682 (1987-06-01), Konz et al.
European Search Report dated Jan. 11, 1994 for corresponding EP Application No. 93 11 5081.

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