Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues
Reexamination Certificate
2004-01-08
2009-02-24
Robinson, Hope A (Department: 1652)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
C530S350000, C530S300000, C435S007100
Reexamination Certificate
active
07495068
ABSTRACT:
Mammalian kringle 5 fragments and kringle 5 fusion proteins are disclosed as a compounds for treating angiogenic diseases. Methods and compositions for inhibiting angiogenic diseases are also disclosed.
REFERENCES:
patent: 5407673 (1995-04-01), Reich et al.
patent: 5512591 (1996-04-01), Halperin et al.
patent: 5854221 (1998-12-01), Cao et al.
patent: 9204450 (1992-03-01), None
patent: 9529242 (1995-11-01), None
patent: 9723500 (1997-02-01), None
“Product News in Brief”, Scrip World Pharmaceutical News, Issue 2120, Apr. 16, 1996.
Fidler, I.J., et al., “The Implications of Angiogenesis for the Biology and Therapy of Cancer Metastasis”,Cell, 79:185-188 (1994).
Folkman, J., “Clinical Applications of Research on Angiogenesis”,The New England Journal of Medicine, 333(26):1757-1763 (1995).
Folkman, J., et al., “Angiogenesis”,Journ. of Biological Chemistry, 267(16):10931-10934 (1992).
Folkman, J., et al., “Angiogenic Factors”,Science, 235:442-447 (1987).
Gasparini, G., et al., “Clinical Importance of the Determination of Tumor Angiogenesis in Breast Carcinoma: Much More Than a New Prognostic Tool”,Journ. of Clinical Oncology, 13(3):765-782 (1995).
Sottrup-Jensen, L., et al., “The Primary Structure of Human Plasminogen: Isolation of Two Lysine-Binding Fragments and One “Mini-” Plasminogen (MW, 38,000) by Elastase-Catalyzed-Specific Limited Proteolysis”,Progress in Chemical Fibrinolysis and Thrombolysis, 3:191-209 (1978).
Kolberg, R., “Angogenic Inhibitor Loss May Be Key To Post-Surgery Metastasis”,Journal of NIH Research, 8:31-33 (1994).
McCance S., et al., “Amino acid residues of the Kringle-4 and Kringle-5 domains of human plasminogen that stabilized their interactions with omega-amino acid ligands”,Journal of Biological Chemistry, 269:32405-32410 (1994).
Menhart, N., et al., “Functional Independence of the Kringle 4 and Kringle 5 Regions of Human Plasminogen”,Biochemistry, 32:8799-8806 (1993).
Novokhatny, V. V., et al., “Domains in Human Plasminogen”,J. Mol. Biol., 179:215-232 (1984).
O'Reilly, M. S., et al., “Angioslalin: A Novel Angiogenesis Inhibitor That Mediates the Suppression of Metastases by a Lewis Lung Carcinoma”,Cell, 79:315-328 (1994).
Teicher, B. A., et al., “Antiangiogenic Agents Can Increase Tumor Oxygenation and Response to Radiation Therapy”,Radiation Oncology Investigations, 2:269-276 (1995).
Teicher, B. A., et al., “Antiangiogenic Agents Potentiate Cytotoxic Cancer Therapies against Primary and Metastatic Disease”,Cancer Research, 52:6702-6704 (1992).
Teicher, B. A., et al., “Antiangiogenic Treatment (TNP-470/Minocycline) Increases Tissue Levels of Anticancer Drugs in Mice Bearing Lewis Lung Carcinoma”,Oncology Research, 7(5):237-243 (1995).
Teicher, B. A., et al., “β-Cyclodextrin tetradecasulfate/tetrahydrocortisol ± minocycline as modulators of cancer therapies in vitro and in vivo against primary and metastatic lewis lung carcinoma”,Cancer Chemother Pharmacol, 33:229-239 (1993).
Teicher, B. A., et al., “Influence of an Anti-Angiogenic Treatment on 9L Gliosarcoma: Oxygenation and Response to Cytotoxic Therapy”,Int. J. Cancer, 61:732-737 (1995).
Teicher, B. A., et al., “Potentiation of Cytotoxic Cancer Therapies by TNP-470 Alone and With Other Anti-Angiogenic Agents”,Int. J. Cancer, 57:920-925 (1994).
Teicher, B. A., et al., “Potentiation of cytotoxic therapies by TNP-470 and minocycline in mice bearing EMT-6 mammary carcinoma”,Breast Cancer Research and Treatment, 36:227-236 (1995).
Thewes, T., et al., “Isolation purification and 1H-NMR characterization of a kringle 5 domain fragment from human plasminogen”,Database Medline, (1987).
Thewest, T., et al., “Ligand Interactions with the Kringle 5 Domain of Plasminogen”,Journal of Biological Chemistry, 265(7):3906-3915 (1990).
Véradi, A., et al., “Kringle 5 of human plasminogen carries a benzamidine-binding site”,Biochemical and biophysical Research Communications, 103:97-102 (1981).
Weidner, N., et al., “Tumor Angiogenesis and Metastasis—Correlation in Invasive Breast Carcinoma”,The New England Journal of Medicine, 324(1):1-8 (1991).
Davidson Donald J.
Gubbins Earl J.
Wang Jieyi
Abbott Laboratories
Reininger Irene M.
Robinson Hope A
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