Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Enzymatic production of a protein or polypeptide
Patent
1997-05-05
2000-05-02
Wax, Robert A.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Enzymatic production of a protein or polypeptide
435 691, 530350, C12P 2106, C07K 100
Patent
active
060571225
ABSTRACT:
Mammalian kringle 5 fragments and kringle 5 fusion proteins are disclosed as a compounds for treating angiogenic diseases. Methods and compositions for inhibiting angiogenic diseases are also disclosed.
REFERENCES:
patent: 5407673 (1995-04-01), Reich et al.
patent: 5512591 (1996-04-01), Halperin et al.
patent: 5854221 (1998-12-01), Cao et al.
McCance, S., et al., "Amino acid residues of the Kringle-4 and Kringle-5 domains of human plasminogen that stabilize their interactions with omega-amino acid ligands", Journal of Biological Chemistry, 269:32405-32410 (1994).
Thewes, T., et al., "Isolation, purification and 1H-NMR characterization of a kringle 5 domain fragment from human plasminogen", Database Medline, 1987.
Varadi, A., et al., "Kringle 5 of human plasminogen carries a benzamidine-binding site", Biochemical and biophysical Research Communications, 103:97-102 (1981).
SCRIP 2120:21 (Apr. 16, 1996).
Fidler, I.J., et al, "The Implications of Angiogenesis for the Biology and Therapy of Cancer Metastasis", Cell, 79:185-188 (1994).
Folkman, J., "Clinical Applications of Research on Angiogenesis", The New England Journal of Medicine, 333(26):1757-1763 (1995).
Folkman, J., et al., "Angiogenesis", Journ. of Biological Chemistry, 267(16):10931-10934 (1992).
Folkman, J., et al., "Angiogenic Factors", Science, 235:442-447 (1987).
Gasparini, G., et al., "Clinical Importance of the Determination of Tumor Angiogenesis in Breast Carcinoma: Much More Than a New Prognostic Tool", Journ. of Clinical Oncology, 13(3):765-782 (1995).
Sottrup-Jensen, L., et al., "The Primary Structure of Human Plasminogen: Isolation of Two Lysine-Binding Fragments and One "Mini-" Plasminogen (MW, 38,000) by Elastase-Catalyzed-Specific Limited Proteolysis", Progess in Chemical Fibrinolysis and Thrombolysis, 3:191-209 (1978).
Kolberg, R., "Angogenic Inhibitor Loss May Be Key To Post-Surgery Metastasis", Journal of NIH Research, 8:31-33 (1994).
Menhart, N., et al., "Functional Independence of the Kringle 4 and Kringle 5 Regions of Human Plasminogen", Biochemistry, 32:8799-8806 (1993).
Novokhatny, V. V., et al., "Domains in Human Plasminogen", J. Mol. Biol., 179:215-232 (1984).
O'Reilly, M. S., et al., "Angiostatin: A Novel Angiogenesis Inhibitor That Mediates the Suppression of Metastases by a Lewis Lung Carcinoma", Cell, 79:315-328 (1994).
Teicher, B. A., et al., "Antiangiogenic Agents Can Increase Tumor Oxygenation and Response to Radiation Therapy", Radiation Oncology Investigations, 2:269-276 (1995).
Teicher, B. A., et al., "Antiangiogenic Agents Potentiate Cytotoxic Cancer Therapies against Primary and Metastatic Disease", Cancer Research, 52:6702-6704 (1992).
Teicher, B. A., et al., "Antiangiogenic Treatment (TNP-470/Minocycline) Increases Tissue Levels of Anticancer Drugs in Mice Bearing Lewis Lung Carcinoma", Oncology Research, 7(5):237-243 (1995).
Teicher, B. A., et al., ".beta.-Cyclodextrin tetradecasulfate/tetrahydrocortisol .+-. minocycline as modulators of cancer therapies in vitro and in vivo against primary and metastatic lewis lung carcinoma", Cancer Chemother Pharmacol, 33:229-239 (1993).
Teicher, B. A., et al., "Influence of an Anti-Angiogenic Treatment on 9L Gliosarcoma: Oxygenation and Response to Cytotoxic Therapy", Int. J. Cancer, 61:732-737 (1995).
Teicher, B. A., et al., "Potentiation of Cytotoxic Cancer Therapies by TNP-470 Alone and With Other Anti-Angiogenic Agents", Int. J. Cancer, 57:920-925 (1994).
Teicher, B. A., et al., "Potentiation of cytotoxic therapies by TNP-470 and minocycline in mice bearing EMT-6 mammary carcinoma", Breast Cancer Research and Treatment, 36:227-236 (1995).
Thewest, T., et al., "Ligand Interactions with the Kringle 5 Domain of Plasminogen", Journal of Blological Chemistry, 265(7):3906-3915 (1990).
Weidner, N., et al., "Tumor Angiogenesis and Metastasis--Correlation in Invasive Breast Carcinoma", The New England Journal of Medicine, 324(1):1-8 (1991).
Abbott Laboratories
Casuto Dianne
Steele Gregory W.
Stole Einar
Wax Robert A.
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