Antiangiogenic peptides

Details Antiangiogenic peptides Antiangiogenic peptides

2005-10-31

2008-05-13

Carlson, Karen Cochrane (Department: 1656)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

24 amino acid residues in defined sequence

C530S300000, C514S013800

Reexamination Certificate

active

07371812

ABSTRACT:
The present invention provides an antiangiogenic polypeptide having the amino acid sequence set forth in SEQ ID NO: 1, or a fragment thereof, which is effective to inhibit endothelial cell proliferation as determined by the capillary EC proliferation assay. Preferably, the fragment has at least 50% inhibition of bFGF-stimulated EC proliferation at 5 μg/ml-20 μg/ml, more preferably 75% inhibition, most preferably 95% inhibition.

REFERENCES:
patent: 2002/0086420 (2002-07-01), Moses et al.
patent: 2003/0027778 (2003-02-01), Fuqua et al.
patent: WO 00/54796 (2000-09-01), None
Stetler-Stevenson et al.,J. of Bio. Chem., 265:13933-13938 (Aug. 15, 1990).
Willenbrock et al.,Biochemistry, 32:4330-4337 (1993).
Salmela et al.,British J. of Cancer, 85(3): 383-392 (2001).

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