Antiandrogenic sulfonylsteroidothiazoles

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai

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540 57, A61K 3158, C07J 7100

Patent

active

050534050

ABSTRACT:
2'-Alkylsulfonylsteroido[3,2-d]thiazoles, for example 2'-methylsulfonyl-5.alpha.-pregn-2-en-20-yno[3,2-d]thiazol-17.beta.-ol, which are useful as antiandrogenic agents, and processes for preparation, method of use and compositions thereof are disclosed.

REFERENCES:
patent: 2813859 (1957-11-01), Korman
patent: 3076801 (1963-02-01), Bowers
patent: 3081228 (1963-03-01), Clinton
patent: 4684636 (1987-08-01), Christiansen et al.
Doorenbos et al., Journal of Pharmaceutical Sciences, vol. 50, p. 271, 1961.
Denes et al., Journal of the Chemical Society, Chemical Communications, Sec. D, No. 11, pp. 621, 1969.
March, Advanced Organic Chemistry p. 1089 (1988).

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