Antiandrogenic sulfonylsteroidooxazoles

Details Antiandrogenic sulfonylsteroidooxazoles Antiandrogenic sulfonylsteroidooxazoles

1990-06-21

1992-07-28

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

540 57, C07J 5100, A61K 3158

Patent

active

051341352

ABSTRACT:
2'-Alkylsulfonylsteroido[2,3-d]oxazoles, for example 2'-methylsulfonyl-5.alpha.-pregn-2-en-20-yno[2,3-d]oxazol-17.beta.-ol, which are useful as antiandrogenic agents, and proceses for preparation, method of use and compositions thereof are disclosed.

REFERENCES:
patent: 4297350 (1981-10-01), Babcock et al.
patent: 4684636 (1987-08-01), Christiansen et al.
Batzold, et al., Drug Development Research 21:29-35 (1990).
Kaneko, et al., Chem. Pharm. Bull. 17(1) 11-22, 1969.
Hadley, Endocrinology [Prentice-Hall Englewood, N.J. 1984] pp. 414-416.
Omar et al., Journal of Pharmaceutical Sciences, vol. 73, pp. 1871-1873, 1984.
Ibrahim et al., Journal of Heterocyclic Chemistry, vol. 19, pp. 761-768, 1982.
Wolloch et al., Tetrahedron, vol. 32, pp. 1289-1292, 1976.
Crabbe et al., Tetrahedron, vol. 27, pp. 711-725, 1971.
Ohta et al., Chemical and Pharmaceutical Bulletin, vol. 16, pp. 1487-1497, 1968.

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