Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Patent
1990-06-21
1992-03-31
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
540 48, C07J 5100, A61K 3158
Patent
active
051008823
ABSTRACT:
5'-Alkylsulfonylsteroido[3,2-b]furans, for example 5'-methylsulfonyl-5.alpha.-pregn-2-en-20-yno[3,2-b]furan-17.beta.-ol having the structural formula, ##STR1## which are useful as antiandrogenic agents, and processes for preparation, method of use and compositions thereof are disclosed.
REFERENCES:
patent: 3146186 (1964-09-01), Orr
patent: 3432486 (1969-03-01), Minato
patent: 4684636 (1987-08-01), Christiansen et al.
Chemical Abstracts vol. 111, 1989 p. 2921F-Formula Index.
Hadley, Endocrinology [Prentice Hall, Englewood Cliffs, N.J., 1984] pp. 386-390.
Orr et al., Steroids, vol. 3, No. 1, pp. 1-12, 1964.
Stefanovic et al., Tetrahedron Letters No. 36, pp. 3311-3312, 1971.
Bell Malcolm R.
Christiansen Robert G.
Kumar Virendra
DuPont Paul E.
Miller Theodore C.
Shah Mukund J.
Sterling Drug Inc.
Ward E. C.
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