Antiandrogenic compounds and methods

Details Antiandrogenic compounds and methods Antiandrogenic compounds and methods

1990-03-30

1992-10-27

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ketone doai

568373, A61K 3112, C07C 49323, C07C 49643

Patent

active

051589818

ABSTRACT:
A antiandrogenic compositions comprising an anti-androgenically effective amount of at least one compound of the formula ##STR1## wherein R is alkyl of 1 to 4 carbon atoms, R.sub.1 is alkyl of 1 to 2 carbon atoms, R.sub.2 is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms optionally interrupted with a heteroatom, alkenyl and alkynyl of 2 to 8 carbon atoms optionally interrupted with a heteroatom, formyl and acyl of an organic carboxylic acid of 2 to 18 carbon atoms, R.sub.3 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and alkenyl and alkynyl of 2 to 4 carbon atoms, R.sub.4 is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, the dotted lines indicate optional presence of a double bond between the 4(5) and 5a(6) carbons and the wavy line indicates that R.sub.4 may be in the .alpha.- or .beta.-position and a non-toxic, pharmaceutical carrier or excipient and a method of treating hyperandrogenic conditions in warm-blooded animals.

REFERENCES:
patent: 3412107 (1968-11-01), Uskovic et al.
patent: 3766248 (1973-10-01), Nedelec et al.
patent: 3984473 (1976-10-01), Hajos
patent: 3984474 (1975-05-01), Sprague et al.
patent: 4492797 (1985-01-01), Furst et al.
J. Org. Chem., 1969, vol. 34 (1), pp. 107-112.

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