Antiandrogenic agent

Details Antiandrogenic agent Antiandrogenic agent

2006-03-28

2006-03-28

Badio, Barbara P. (Department: 1617)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

C514S179000, C552S638000, C552S641000

Reexamination Certificate

active

07018993

ABSTRACT:
A compound pf general formula (I):wherein, for example,X1and X2independently represent a hydrogen atom.Rarepresents a hydrogen atom or a protecting group for a hydroxyl group.Rband Rcform an optionally protected —(C═O)— together with the 3-position carbon atom attached to Rband Rc, andthe broken line forms a single bond or double bond together with the solid line, or a pharmaceutically acceptable salt of the compound or a prodrug thereof.

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Bourguet et al., “Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α”,Nature, (1995), vol. 375, pp. 377-382.

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