Antiamyloid phenylsulfonamides: N-alkanol derivatives

Details Antiamyloid phenylsulfonamides: N-alkanol derivatives Antiamyloid phenylsulfonamides: N-alkanol derivatives

2006-01-24

2006-01-24

Shameem, Golam M. M. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S300100, C548S335100, C548S335500, C514S396000

Reexamination Certificate

active

06989399

ABSTRACT:
A series of N-alkanol-N-phenyl benzenesulfonamide and related derivatives of the Formula I are disclosed,wherein R1, R2, R3, X, and Y are defined herein. The compounds are inhibitors of β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions characterized by aberrant extracellular deposition of amyloid. Pharmaceutical compositions and methods of treatment are also disclosed.

REFERENCES:
patent: 5880151 (1999-03-01), Medina et al.
patent: 6121304 (2000-09-01), Flygare et al.
patent: 6448290 (2002-09-01), Ohuchida et al.
patent: 0815861 (2001-09-01), None
patent: WO 00/50391 (2000-08-01), None

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