Antiallergic composition containing aromatic carboxylic amide de

Details Antiallergic composition containing aromatic carboxylic amide de Antiallergic composition containing aromatic carboxylic amide de

1976-12-21

1978-01-24

Rosen, Sam

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

424278, 424282, A61K 31195, A61K 31335, A61K 3136

Patent

active

040704840

ABSTRACT:
Aromatic carboxylic amides of the general formula: ##STR1## wherein each of R.sub.1 and R.sub.2 is a hydrogen atom or an alkyl group having 1-4 carbon atoms, R.sub.3 and R.sub.4 are hydrogen atoms or together form another chemical bond, each X is a hydroxyl group, a halogen atom, an alkyl group having 1-4 carbon atoms and an alkoxyl group containing 1-4 carbon atoms, and may be the same or different, and n is an integer of 1-3, provided that when two Xs are alkyl or alkoxyl groups, the alkyl groups thereof may be connected together into an alkylene group, and the pharmaceutically acceptable salts thereof, possess a strong antiallergic action and are thus useful for treatment of asthma, hay fever, urticaria and atopic dermatitis.

REFERENCES:
patent: 3655743 (1972-04-01), Nickl et al.
patent: 3758528 (1973-09-01), Malen et al.
Nossier et al. - J. Chem. U.A.R. (1969), vol. 12, No. 1, pp. 57-68.
Seka et al. - Monatsh, 53-54, (1929), pp. 471-484.
Karmarkar et al., J. Indian Chem. Soc., vol. 30, (1953), pp. 689-694.
Nossier et al. - U.A.R. J. Chem., vol. 13, No. 4, (1970), pp. 379-390.

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