Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ketone doai
Reexamination Certificate
1999-11-15
2001-05-08
Krass, Frederick (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ketone doai
C514S826000, C514S862000, C514S885000, C514S886000, C426S590000, C426S531000, C426S625000, C426S653000
Reexamination Certificate
active
06228892
ABSTRACT:
TECHNICAL FIELD OF THE INVENTION
The present invention relates to drug, food and beverage which are useful for therapy of allergic diseases.
Prior Art
In allergic diseases represented by asthma and atopic dermatitis, release of chemical mediators from mast cells plays a big role in the allergic reaction. This reaction is induced by binding the immunoglobulin E (IgE) to receptors on cell membranes followed by cross-linking and it is expected that an inhibitor of the IgE production plays an effect for therapy and prevention of allergic diseases.
The reaction of the delayed type hypersensitivity is an inflammatory reaction depending upon cellular immune induced by T lymphocytes activated by antigen which is not removed by macrophage. Inflammatory cells are induced and activated by cytokine which is produced from activated T lymphocytes and release various inflammatory mediators to induce tissue disturbances. Allergic dermatitis by a reaction of the delayed type hypersensitivity occupies a high percentage of contact-type dermatitis and, in addition, it is a cause of onset of allergy where bacteria, virus or drugs are antigens. Thus, it is expected that an inhibitor of the delayed type hypersensitivity plays an effect for therapy and prevention of those allergic diseases.
Problems to be Solved by the Invention
An object of the present invention is to develop a compound which is effective for controlling the IgE production and for inhibiting the reaction of the delayed type hypersensitivity and to offer a drug which is useful for the therapy of allergic diseases containing said compound as an effective component, a method for the inhibition of allergy using said compound as an effective component and food and beverage containing said compound.
Means to Solve the Problem
In order to achieve the above-mentioned object, the present inventors have conducted an intensive investigation and found that 4,5-dihydroxy-2-cyclopenten-1-one which is a compound represented by the formula [I] (hereinafter, just referred to as “the cyclopentenone”) has an inhibition activity of IgE production and an inhibition activity of delayed type hypersensitivity, and said compound is useful as an effective component of an antiallergic agent whereupon the present invention has been accomplished.
Outline of the present invention is that the first feature of the present invention relates to an antiallergic agent which is characterized in containing at least one compound selected from a group consisting of 4,5-dihydroxy-2-cyclopenten-1-one represented by the following formula [I] and an optically active substance and a salt thereof as an effective component.
The second feature of the present invention relates to a method for inhibiting allergies which is characterized in using at least one compound selected from a group consisting of 4,5-dihydroxy-2-cyclopenten-1-one represented by the above-mentioned formula [I] and an optically active substance and a salt thereof as an effective component.
The third feature of the present invention relates to an antiallergic food or beverage which is characterized in containing at least one compound selected from a group consisting of 4,5-dihydroxy-2-cyclopenten-1-one represented by the above-mentioned formula [I] and an optically active substance and a salt thereof as an effective component.
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Cocu et al, Helvetica Chimica Acta, vol. 55, Fasc. 8 (Apr. 1972), Nr. 286, 2838-2844, “Recherches Dans La Serie Des Cyclitols”.*
Ahmad et al, Carbohydrate Research, 247 (Jun. 1993) 217-222, “On the Formation of Reductic Acid From Pentoses or Hexuronic Acids”.*
Translation of Japanese Patent Publication (Kokai) No. Sho-50-70597 (1973).
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Hagiya Michio
Kato Ikunoshin
Koyama Nobuto
Nishiyama Eiji
Tominaga Takanari
Kennedy Covington Lobdell & Hickman L.L.P.
Krass Frederick
Takara Shuzo Co. Ltd.
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