Antiallergic agent

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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Reexamination Certificate

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10525567

ABSTRACT:
It is intended to provide an anti-allergic agent, which efficaciously relieves symptoms accompanying an allergic disease without causing any serious side effect. This object is achieved by providing an anti-allergic agent which contains, as an effective ingredient, proteins collected from royal jelly or purified royal jelly, or royal jelly or purified royal jelly containing the proteins.

REFERENCES:
patent: 6165982 (2000-12-01), Yamada et al.
patent: 100236/97 (1997-04-01), None
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Article: Benefits of Royal Jelly, updated on Feb. 16, 2006, pp. 1-3.
Schmitzova J et al “A family of major royal jelly proteins of the honeybee Apis Mellifera L.” Cellular and Molecular Life Sciences, (1998) vol. 54, pp. 1020-1030.
Hideki Oka et al “Th Saibo Otosei no Chosetsu o Kaishita, Royal jelly no Allergy Han'no Yokusei Sayo”, Biotherapy (Tokyo), (2000) vol. 14, No. 2, pp. 145-150.
Mari Kataoka et al “Royal jelly no Ko-Allergy Sayo no Kento” Nat. Med., (2001), vol. 55, No. 4, pp. 174-180.
Oka H et al “Suppression of allergic reactions by royal jelly in association with the restoration of macrophage function and the improvement of Th1/Th2 cell responses”, Int. Immunopharmacol., (2001), pp. 521-532.
Alberts S et al “Molecular characterization of MRJP3, highly polymorphic protein of honeybee (Apis Mellifera) royal jelly”, Insect Biochem. Mol. Biol., (1999) pp. 427-434.

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