Antiallergic (1H-tetrazol-5-yl)tetrazolo[1,5-a]quinolines and de

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514381, 514312, 514314, 546122, 546176, 546 65, 546 82, A61K 3147, A61K 3144, C07D47104, C07D47114

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active

044965699

ABSTRACT:
(1H-Tetrazol-5-yl)tetrazolo[1,5-a]quinolines and related compounds which are useful as antiallergic agents are described herein. The compounds are prepared by the reaction of an appropriate halocyanoquinoline or isoquinoline with ammonium chloride and an azide such as sodium azide in an inert solvent such dimethylformamide.

REFERENCES:
patent: 3764681 (1973-10-01), Dreikorn
Fieser, M., et al., Reagents For Organic Synthesis, vol. 2, Wiley-Interscience, NY, 1969, p. 376.
Chemical Abstracts, 88:137453m (1978)[Ger. Offen. 2,731,323, Illy, 1/26/78].
Meth-Cohn, O., et al., J. Chem. Soc. Perkin Trans I, 2509-2517 (1981).
Reimlinger, H., et al., Chem. Ber. 108, 3780-3786 (1975).
Livi, O., et al. Il Farmaco, Ed. Sci., 30 (12), 1017 (1975).
Ferrarini, P., et al., Il Farmaco, Ed. Sci., 33 (7), 543 (1978).
Erickson, E., et al., J. Med. Chem., 22 (7), 816-823 (1979).

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