Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2011-05-17
2011-05-17
Blanchard, David J. (Department: 1643)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S388100, C530S388220, C530S388800, C424S133100, C424S141100, C424S143100, C424S155100, C435S069600, C435S070210
Reexamination Certificate
active
07943742
ABSTRACT:
The present invention is in the fields of cell biology, immunology and oncology. The invention provides humanized antibodies that recognize αvβ6integrins, which antibodies comprise a variable region of nonhuman origin and at least a portion of an immunoglobulin of human origin. The invention also provides methods for preparation of such antibodies, pharmaceutical compositions comprising them, and methods of treating, diagnosing and/or preventing various diseases and disorders by administering the humanized anti-αvβ6antibodies of the invention. The invention also relates to the identification of differential expression of the integrin αvβ6on the surfaces of tumor cells and tissues, the use of this differential expression in determining the metastatic potential of tumor cells, and methods of diagnosis and treatment/prevention of tumor metastasis and for elimination of residual metastatic tumor cells using ligands, particularly antibodies, that bind to integrin αvβ6.
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Koopman Louise A.
Lugovskoy Alexey A.
Saldanha José W.
Simon Kenneth J.
van Vlijmen Herman W. T.
Biogen Idec MA Inc.
Blanchard David J.
McAndrews Held & Malloy Ltd.
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