Anti-viral treatment with pertussis toxin B oligomer

Details Anti-viral treatment with pertussis toxin B oligomer Anti-viral treatment with pertussis toxin B oligomer

1997-08-15

2000-02-01

Stucker, Jeffrey

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

4241841, 4242011, 4242081, 4242541, 4242821, 514 2, A01N 3718

Patent

active

060199792

ABSTRACT:
There is disclosed a method for anti-viral therapy treatment with the Pertussis toxin beta subunit oligomer, wherein the oligomer is composed of from two to ten subunits of PTX selected from the group consisting of S2, S3, S4, S5, and combinations thereof.

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Ui, "Pertussis Toxin as a Valuable Probe for G-Protein Involvement in Signal Transduction".
Chong et al. Infection Immunity 60:4640-4647, 1992.
Wong and Rosoff, Can. J. Physiol. Pharmacol. 74:559-564, 1996.
Oka et al., "Enhancing Effects of Pertussis Toxin B Oligomer on the Immunogenicity of Influenza Vaccine Administered Intranasally", Vaccine, vol. 12, No. 14(1994), pp. 1255-1258.
Kenealy et al. "Antibodies from Human Immunodeficiency Virus-Infected Individuals Bind to a Short Amino Acid Sequence that Elicits Neutralizing Antibodies in Animals", AIDS Research and Human Retroviruses, vol. 5, No. 2(1989), pp. 173-182.
Chowdhury et al. "Pertussis Toxin Inhibits Induction of Human Immunodeficiency Virus Type 1 in Infected Monocytes" Virology, vol. 203, No. 2(Sep. 1994), pp. 378-383. QR1.V5.

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