Anti-viral pyrimidine nucleoside analogues

Details Anti-viral pyrimidine nucleoside analogues Anti-viral pyrimidine nucleoside analogues

2001-04-12

2010-10-26

Olson, Eric S (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S049000, C514S052000, C514S268000, C514S260100, C514S265100, C536S027200, C536S027130, C544S244000, C544S278000, C544S279000

Reexamination Certificate

active

07820631

ABSTRACT:
A nucleoside analogue compound is provided which has a six-membered aromatic ring system, the aromatic ring system being substituted in the para position with an unbranched unsubstituted alkyl or alkoxy moiety, wherein the alkyl or alkoxy moiety, in total, has from 3 to 8 carbon atoms. This compound shows anti-vira1 activity, for example with respect to varicella zoster virus and can thus be used in therapeutic methods for the prophylaxis and treatment of viral infections such as varicella zoster virus.

REFERENCES:
patent: 6573247 (2003-06-01), McGuigan et al.
patent: WO 96/29336 (1996-09-01), None
patent: WO 98/49177 (1998-11-01), None
De Clercq et al., “Antiviral Drugs in Current Clinical Use” Journal of Clinical Virology (2004) vol. 30, pp. 115-133.
U.S. Appl. No. 12/226,044, filed Oct. 2008, McGuigan, Christopher.
Silverman, R. The Organic Chemistry of Drug Design and Drug Action, “Chapter 8: Prodrugs and Drug Delivery Systems” Published 1992 by Academic Press, pp. 352-397.
Crisp, G.T., et al., “Palladium-catalyzed coupling of terminal alkynes with 5-(trifluoromethanesulfonyloxy) pyrimidine nucleosides,”J. Org. Chem., 1993, 58(24), 6614-6619 (Chemical Abstract No. 119:271599, 3 pages).
Malakhova, E.V., et al., “Reagents for introducing a fluorescent deoxyuridine 2-phenylbenzoxazola derivative into oligonucleotides,”Bioorg. Khim., 1998, 24(9), 688-695 (Chemical Abstract No. 130:352490, 2 pages).
Tolstikov, G.A., et al., “Novel type of interaction of 5-iodopyrimidinonucleosides with alkynes,”Izv. Akad. Nauk, Ser. Khim., 1992, 6, 1449-1450 (Chemical Abstract No. 118:124938, 2 pages).
Tolstikov, G.A., et al., “New type of reaction of 5-idopyrimidine nucleosides with alkynes,”Izv. Akad. Nauk, Ser. Khim., 1993, 3, 596-598 (Chemical Abstract No. 124:87652, 2 pages).
Brancale, A. et al., “Synthesis and anti-varicella-zoster virus activity of some nove bicyclic nucleoside inhibitors; effect of enhanced aqueous solubility”,Antiviral Chem. Chemother, 2000, 11(6), 383-393.
Crisp, G.T. et al., “Palladium-Catalyzed Coupling of Terminal Alkynes with 5(Trifluoromethanesulfonyloxy) Pyrimidine Nucleosides”,Journal of Organic Chemistry, 1993, 58(24), 6614-6619.
DeClercq, E. et al., “(E)-5-(2-Bromovinyl)-2′-deoxyuridine: A potent and selective anti-herpes agent”,Proc. Natl. Acad. Sci., USA, 1979, 76(6), 2947-2951.
Kerr, C.E. et al., “Synthesis of N, N-dialkylaniline-2′-deoxyuridine conjugates for DNA-mediated electron transfer studies”,Nucleosides, Nucleotides Nucleic Acids, 2000, 19(5&6), 851-866.
Malakhova, E.V. et al., “Reagents for introducing a fluorescent deoxyuridine 2-phenylbenzoxazole derivative into oligonucleotides”,Bioorg. Khim, 1998, 24(9), 688-695.
McGuigan, C. et al., “Potent and Selective Inhibition of Varicella-Zoster Virus(VZV) by Nucleoside Analogues with Unusual Bicyclic Base”,J. Med. Chem, 1999, 42(22), 4479-4484.
McGuigan, C. et al., “Highly Potent and Selective Inhibition of Varicella-Zoster Viru by Bicyclic Furopyrimidine Nucleosides Bearing an Aryl Side Chain”,J. Med. Chem, 2000, 43(26), 4993-4997.

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