Anti-viral pyrimidine nucleoside analogues

Details Anti-viral pyrimidine nucleoside analogues Anti-viral pyrimidine nucleoside analogues

2006-03-28

2006-03-28

Ward, Paul V (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C544S278000, C536S027130, C514S265100, C514S260100, C514S260100, C514S043000

Reexamination Certificate

active

07019135

ABSTRACT:
Compounds of the general formula (I)are described wherein R, R′, R″, Q, T, T′, T″, T″′, W, X, and Z are as defined in the specification. Compounds according to the invention preferably display potent anti-viral activity against, for example, cytomegalo virus.

REFERENCES:
patent: WO 98/49177 (1998-11-01), None
Mauro Magnani et al., “Synthesis and targeted delivery of an azidothymidine homodinucleotide conferring protection to macrophages against retroviral infection”, Proc. Nat'l. Acad. Sci. USA. vol. 93, pp. 4403-4408, Apr. 1996. Med. Sciences.
Crisp, G.T., et al., “Palladium-catalyzed coupling of terminal alkynes with 5-(trifluoromethanesulfonyloxy) pyrimidine nucleosides,”J. Org. Chem., 1993, 58, 6614-6619.
Criuckshank, K.A., et al., “Oligonucleotide labeling: A concise synthesis of a modified thymidine phosphoramidite,”Tetrahedron Letters, 1988, 29(41), 5221-5224.
De Clercq, E., et al., “Nucleic acid related compounds. 40. Synthesis and biological activities of 5-alkynyluracil nucleosides,”J. Med. Chem., 1983, 26, 661-666.
Inoue, H., et al., “Preparation of fluorescent nucleosides or nucleotides and their use for DNA hybridization probes,”Teljin Ltd., Japan, (JP 62255499), 4 pages (abstract).
Inoue, H., et al., “Synthesis of dodecadeoxyribonucleotides containing a pyrrolo[2,3-d]pyrimidine nucleoside and their base-pairing ability,”Nippon Kagaku Kaishi, 1987, ISSN: 0369-4577, 2 pages (abstract).
Kumar, R., et al., “Synthesis of 5-(1-azidovinyl) and 5-[2-(1-azirinyl)] analogs of 2′-deoxyuridine,”Can. J. Chem., 1996, 74, 1609-1615.
Kumar, H., et al., “Synthesis and properties of 5-(1,2-dihaloethyl)-2′deoxyuridines and related analogues,”J. Heterocyclic Chem., 1991, 28, 1917-1925.
McGuigan, C., et al., “Potent and selective inhibition of varicella-zoster virus (VZV) by nucleoside analogues with an unusual bicyclic base,”J. Med. Chem., 1999, 42, XP-002177282, 4479-4484.
Robins, M.J., et al., “Nucleic acid related compounds. 39. Efficient conversion of 5-iodo to 5-alkynyl and derived 5-substituted uracil bases and nucleosides,”J. Org. Chem., 1983, 48, 1854-1862.
Robins M.J., et al., “Nucleic acid related compounds. 31. Smooth and efficient palladium-copper catalyzed coupling of terminal alkynes with 5-iodouracil nucleosides,”Tetrahedron Letters, 1981, 22, 421-424.
Woo, J., et al., “G/C-modified oligodeoxynucleotides with selective complementarity: synthesis and hybridization properties,”Nucleic Acids Research, 1996, 24(13), 2470-2475.

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