Anti-viral N-substituted pyrimidines

Details Anti-viral N-substituted pyrimidines Anti-viral N-substituted pyrimidines

1987-03-09

1989-09-19

Shen, Cecelia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514245, 514274, 544194, 544229, 544211, 544313, 544314, 544317, A61K 31505, C07D23930, C07D23947, C07D23955

Patent

active

048681873

ABSTRACT:
Nucleoside analogues having a ring-open structure, of general formula: ##STR1## where R and R' may be hydrogen, silyl groups, substituted alkyl groups, benzyl groups and the like, and X is an optionally substituted base such as guanine or adenine, have been shown to exhibit anti-viral and other biological acivities at non-toxic levels.

REFERENCES:
patent: 4146715 (1979-03-01), Schaeffer
patent: 4171431 (1979-10-01), Skulnick
patent: 4501744 (1985-02-01), Ogilvie
patent: 4508898 (1985-04-01), Ogilvie
Ogilvie et al., CA 100-192208b.
Martin et al., CA 102-95995q.
Ogilvie, CA 103-71626q.
Takaku et al., CA 108-204992h.

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