Anti-viral methods using RNAse and DNAse

Details Anti-viral methods using RNAse and DNAse Anti-viral methods using RNAse and DNAse

1995-03-17

1996-01-16

Knode, Marian C.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Multienzyme complexes or mixtures of enzymes

424 946, A61K 3854

Patent

active

054845890

ABSTRACT:
Methods for the treatment and prevention of human, animal and plant viral infections are provided. The methods consist of administering to an infected human, animal or plant an effective amount of DNase and RNase or other nuclease exhibiting properties of both enzymes, preferably in conjunction with a suitable divalent cation activator. The effective amount preferably provides a systemic or local concentration between about 5.times.10.sup.-3 to 10.times.10.sup.-3 Kunitz units of activity of each nuclease per ml of body fluids and between about 0.1 to 0.3 Kunitz units or more per ml of solution for incubating, growing, soaking or spraying plant seeds, microclones, seedlings or adult plants.

REFERENCES:
Trukhachov et al., Virology 3:552-555 (1967).
Glukhov et al., Arch. Neurol. 33:598-603 (1976).
Demin, Lancet, Jun. 26, 1976.
Colain et al., Ann. Oculist 203:371-378 (1970).
Gutorov et al., 1976.
Ehara et al., CA 106:116428, 1987.
Mink CA 82:106898, 1975.
Salganik, CA 73:32619, 1970.
Boerner et al., CA 111:28548, 1989.
Salganik et al., CA 85:103795, 1976.
D'Yachenko et al., BA 87(1):2190, 1988.

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