Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1984-06-06
1989-03-28
Rizzo, Nicholas S.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
544244, 544276, 544277, C07D47318, A61K 3152
Patent
active
048164470
ABSTRACT:
9-(1,3-Dihydroxy-2-propoxymethyl)guanine and 9-(2,3-dihydroxy-1-propoxymethyl)guanine have been found to have potent anti-viral activity against herpes viruses. These compounds, their acyl derivatives, their phosphate derivatives and their pharmaceutically acceptable salts, pharmaceutical formulations containing these compounds, the treatment of DNA viral or herpes viral infections with these compounds, method of preparing these compounds, and novel intermediates useful in their preparation are all disclosed.
The compounds may be prepared by reaction of the appropriate acetoxymethyl ether with diacetylguanine, followed by deprotection. The acetoxymethyl ethers may be obtained by reaction of glycerol formal with acetic anhydride in the presence of a catalyst.
REFERENCES:
patent: 4199574 (1980-04-01), Schaeffer
patent: 4287188 (1981-09-01), Schaeffer
patent: 4590269 (1986-05-01), Onisbe et al.
patent: 4603219 (1986-07-01), Verheyden et al.
patent: 4670424 (1987-06-01), Mac Ross et al.
Ashton Wallace T.
Field Arthur K.
Karkas John D.
Tolman Richard L.
Merck & Co. , Inc.
Parr Richard S.
Pfeiffer Hesna J.
Rizzo Nicholas S.
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