Anti-viral compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 86, 544243, 544244, 549 6, 549 7, 549 30, 549 37, 549216, 549218, 549449, 549475, 549476, A61K 31675, C07F 96512

Patent

active

057893942

ABSTRACT:
Nucleotide analogues having the general formula (I) and pharmaceutically acceptable derivatives: ##STR1## wherein n is 0 or an integer; X is O or S, CH.sub.2, CH-halogen, CH--N.sub.3, or C.dbd.CH.sub.2 ;

REFERENCES:
patent: 5118672 (1992-06-01), Schinazi et al.
patent: 5159067 (1992-10-01), Schinazi et al.
Y. aly et al., "Synthesis of 2', 5'-Dideoxyuridine-5'-phosphonates," Liebigs Ann. Chem., 1992, pp. 127-129 (1992).
J. Bronson et al., "Synthesis and Biological Activity of Carbocyclic guanine (PMEG)," Bioorg. Med. Chem. Lett., 2, pp. 685-690 (1992).
A. Charvet et al., "Inhibition of Human Immunodeficiency Virus Type I Replication by Phosphonoformate-and Phosphonacetate-2', 3'-Dideoxy-3'-thiacytidine conjugates," J. Med. Chem., 37, pp. 2216-2223 (1994).
A. Duke et al., "In Vitro and In Vivo Activities of Phosphate Derivatives of 9-(1,3-Dihydroxy-2-propoxymethyl)-guanine against cytomegaloviruses," Antiviral Res., 6, pp. 299-308 (1986).
C. Kim et al., "Synthesis and HIV Activity of Phosphonate Isosteres of D4T Monophosphate," Bioorg. Med. Chem. Lett., 2, pp. 367-370 (1992).
J. Kraus, "new Phosphonate Analogues of 3'-Thia-2', 3'-dideoxycytidine (BCH-189):Synthesis and Anti-HIV Evaluation," Nucleosides & Nucleotides, 12, pp. 157-162 (1993).
S. Miyasaka and H. Tanaka, "Preparation of Virucidal 3'-deoxy-3'-azidonucleoside 5'-Phosphonic Acids," Chem. Abstracts, 114, No. 122988w, p. 861 (1991). -A Novel Type of Nucleotide Analogs Related to HPMPA. I. Derivatives With L-arabino, D-arabino, 2-Deoxy-L-erythro And 2-Deoxy-L-threo Configuration," Collect. Czech. Chem. Commun., 58, pp. 2159-2179 (1993). -A Novel Type of Nucleotide Analogs Related to HPMPA. II. Synthesis of L-ribo and L-xylo Configurated Derivatives By Recyclization of Diethyl s-5-C-yl!phosphonates Under Acidic Conditions," Collect. Czech. Chem. Commun., 58, pp. 2180-2196 (1993).
J. Secrist, III et al., "Syntheses of Phosphonate Analogues of Dideoxyadenosine (DDA)-, Dideoxycytidine (DDC)-, Dideoxyinosine (DDI)-, and Deoxythymidine (DDT)-5'-Monophosphates," Nucleosides & Nucleotides, 11, pp. 947-956 (1992).
J. Starrett, Jr. et al., "Synthesis and In Vitro Evaluation of a Phosphonate Prodrug: Bis(pivaloyloxymethyl) 9-(2-phosphonylmethoxyethyl) adenine," Antiviral Res., 19, pp. 267-273 (1992).
H. Tanaka, et al., "Cleavage of a Nucleosidic Oxetane with Carbanions: Synthesis of a Highly Promising Candidate for Anti-HIV Agents --A Phosphonate Isostere of AZT 5'-Phosphate," Tetrahedron Lett., 30, pp. 2567-2570 (1989).
Aggarwal et al, J. Med. Chem. 33, pp. 1505-1510 (1990).
Bundgaard, Drugs Of The Future 16, pp. 443-458 (1991).
Efimtseva et al, Nucleosides & Nucleotides, 14 pp. 727-729 (Jun. 1995).
Meier et al, J. Medicinal Chem. Letters vol. 1, pp. 527-530 (1991).
Pochet et al, Tetrahedron Letters, 31, pp. 6021-6024 (1990).
Chu et al, J. Med. Chem. 33, pp. 2188-2192 (1990).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Anti-viral compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Anti-viral compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-viral compounds will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1177323

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.