Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-08-30
1997-06-03
Carr, Deborah D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514332, 514964, 514966, 424434, 424436, 424487, 424488, 5462737, A61K 3144
Patent
active
056355203
ABSTRACT:
The present invention relates to a composition for rectal administration which comprises a benzimidazole compound having antiulcer activity and a salt of C.sub.6-20 fatty acid, both of which are intermingled with each other in a base for rectal administration.
The composition for rectal administration of the present invention is effective for the treatment of gastrointestinal ulcers, is excellent in the stability of the active ingredient therein and the absorption thereof to thereby insure an early attainment of therapeutically effective blood concentration and permits control of the rate of absorption of the drug. Furthermore, the composition for rectal administration of the present invention swells in the intestinal tract, attaches itself to the mucosa, and releases the active ingredient gradually over a long time to supply the drug at a high concentration and with high efficiency. Therefore, the expected therapeutic efficacy can be obtained at a low dosage level with a minimum of side effect.
REFERENCES:
patent: 4738974 (1988-04-01), Brandstrom
patent: 5219870 (1993-06-01), Kim
patent: 5223515 (1993-06-01), Mikura et al.
Glycyrrhizin suppository with improved rectal absorption . . . , Derwent Publications Ltd., AN92-360693. Jan. 1992.
Preparations for rectal admin . . . , Derwent Publications Ltd., AN 82-87046E, 1982
Carr Deborah D.
Takeda Chemical Industries Ltd.
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