Anti-ulcer agent

Details Anti-ulcer agent Anti-ulcer agent

1992-05-15

1993-09-14

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514212, 514218, 514307, 514308, 540575, 540597, 544363, 546140, 546146, 546148, A61K 3155, A61K 31495, C07D40100

Patent

active

052448959

ABSTRACT:
An anti-ulcer agent contains a compound expressed by the following general formula 1: ##STR1## where, R.sub.1 is hydrogen atom or an alkyl group having 1 or 2 carbon atoms with or without substitution, R.sub.2 and R.sub.3 are resp. hydrogen atom or form oxo group together, R.sub.4 is hydrogen atom or methyl group or isoquinoline sulfonyl group, n is 2 or 3, A is N--R.sub.5 or CH--R.sub.5, R.sub.5 is phenyl group with or without substitution or benzyloxycarbonyl group with or without substitution, or a physiologically allowable acid added salt thereof as the active component.

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Chemical Abstracts, 68730b, vol. 100, 1984, & JP-58 33 866, p. 642, "Tyrosinol Derivatives".
Chemical Abstracts, 233042m, vol. 112, 1990, p. 399, & J. Biol. Chem. 1990, 265(8), pp. 4315-4320, H. Tokumitsu, et al., "KN-62, 1-[N,O-Bis(5-isoquinolinesulfonyl) --N-- Methyl--L--Tyrosyl]--4--Phenylpiperazine, A Specific Inhibitor of Calcium/Calmodulin-Dependent Protein Kinase II".

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