Anti-ulcer 5-(2-substituted ethenyl)-3(2H)-furanones

Details Anti-ulcer 5-(2-substituted ethenyl)-3(2H)-furanones Anti-ulcer 5-(2-substituted ethenyl)-3(2H)-furanones

1990-08-23

1991-04-23

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549479, A61K 3134, C07D30702

Patent

active

050101021

ABSTRACT:
A compound of the formula: ##STR1## in which R is alkyl, phenyl or halophenyl; R.sup.2 is substituted phenyl having from 1 to 3 substiuents selected from halo, alkyl, alkylthio, alkylsulfonyl, cyano, trifluoromethyl, or R.sup.2 is pyridinyl, pyrazinyl, quinolinyl, N-alkylpyrrolyl, thienyl, benzothienyl, or furyl; and n is 1 or 2, are cytoprotective anti-ulcer agents.

REFERENCES:
Tsuge et al., Chem. Letters 323 (1987).
Takashi et al., Chem. Abstracts, vol. 108, No. 13; 112103r (1988).
Tsuge et al., Chem. Abstracts, vol. 107, No. 19, 175802t (1987).
Ito et al., Chem. Abstracts, vol. 96, No. 17, 142535j (1982).

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