Anti-ulcer 5-(2-substituted ethenyl)-3(2H)-furanones

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514444, 549 58, 549 60, A61K 3134, C07D33356, C07D40902

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active

050176013

ABSTRACT:
A compound of the formula: ##STR1## in which R is alkyl, phenyl or halophenyl; R.sup.2 is substituted phenyl having from 1 to 3 substituents selected from halo, alkyl, alkythio, alkylsulfonyl, cyano, trifluoromethyl, or R.sup.2 is pyridinyl, pyrazinyl, quinolinyl, N-alkylpyrrolyl, thienyl, benzothienyl, or furyl; and n is 1 or 2, are cytoprotective anti-ulcer agents.

REFERENCES:
Tsuge et al., Chem. Letters 323 (1987).
Takashi et al., Chem. Abstracts, vol. 108, No. 13; 112103r (1988).
Tsuge et al., Chem. Abstracts, vol. 107, No. 19, 175802t (1987).
Ito et al., Chem. Abstracts, vol. 96, No. 17, 142535j (1982).

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