Anti-tumor substance of immunoglobulin and melphalan and process

Details Anti-tumor substance of immunoglobulin and melphalan and process Anti-tumor substance of immunoglobulin and melphalan and process

1987-01-20

1988-04-19

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Lymphokine

424 88, 514 8, 530388, 530389, 530390, 530391, A61K 3944

Patent

active

047388439

ABSTRACT:
Disclosed herein are an anti-tumor substance obtained by bonding an anti-tumor agent to human immunoglobulin, and a process for producing the same.

REFERENCES:
patent: 4017471 (1977-04-01), Davies
patent: 4046722 (1977-09-01), Rowland
patent: 4093607 (1978-06-01), Sela et al.
patent: 4263279 (1981-04-01), Sela et al.
patent: 4315851 (1982-02-01), Yoshikumi et al.
patent: 4340535 (1982-07-01), Voisin et al.
patent: 4350626 (1982-09-01), Masuho et al.
patent: 4359457 (1982-11-01), Neville, Jr. et al.
patent: 4401592 (1983-08-01), Yoshikumi et al.
patent: 4414148 (1983-11-01), Jansen et al.
patent: 4487714 (1984-12-01), Kato et al.
patent: 4489710 (1984-12-01), Spitler
patent: 4493793 (1985-01-01), Chu
Biochem. Soc. Trans., 10(6), 1982, p. 505, Melino et al.
Europ. J. Cancer, 13 (1977), 593-596, Rowland.
Int. J. Cancer, 21 (1978), 747-755, Hurwitz et al.
Cancer Research, 41, 2700-2706 (1981), Kulkarni et al.
J. Natl. Cancer Institute, 60 (1978), 379-384, Bernstein et al.
Chem. Pharm. Bull, vol. 29, 1981, pp. 844-848, JP; T. Suzuki: "The Preparation of Mitomycin C, Adriamycin and Daunomycin Covalently Bound to Antibodies as Improved Cancer Chemotherapeutic Agents".
Chem. Abstracts, vol. 99, 1983, p. 30, No. 169139g, P. Hazarika et al.: "Protein-Bound Daunorubicin as an Agent for Cancer Therapy".
Chemical Abstracts, vol. 95, 1981, p. 27, No. 73122n, P. N. Kulkarni et al.: "Covalent Binding of Methotrexate to Immunoglobulins and the Effect of Antibody-Linked Drug on Tumor Growth in Vivo".
Chemical Abstracts, vol. 92, 1980, p. 58, No. 104379w, J. Tai et al.: "Tumor Inhibition by Chlorambucil Covalently Linked to Antitumor Globulin".
Biological Abstracts, vol. 62, 1976, No. 44481, E. Hurwitz et al., "FAB Dimers of Antitumor Immunoglobulins as Covalent Carriers of Daunomycin".

Affiliated with

Also associated with

Rating

Anti-tumor substance of immunoglobulin and melphalan and process does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Anti-tumor substance of immunoglobulin and melphalan and process, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-tumor substance of immunoglobulin and melphalan and process will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2174436