Anti-tumor platinum(II) complexes and process for the preparatio

Details Anti-tumor platinum(II) complexes and process for the preparatio Anti-tumor platinum(II) complexes and process for the preparatio

1991-11-22

1992-08-25

Prescott, Arthur C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heavy metal containing

C07F 1500

Patent

active

051420759

ABSTRACT:
The present invention relates to anti-tumor platinum complexes represented by the general formula I: ##STR1## wherein A is selected from the group consisting of ammine and mondentate primary alkyl- and cycloalkylamines having 1-3 carbon atoms such as methyl, ethyl, n-propyl-, isopropyl- and cyclopropylamines, or the two amine groups may be combined to be a bidentate diamine of the chelating form AA such as ethylenediamine, 1,2-diaminocyclohexane, and 2-hydroxy-1,3-diaminopropane, and X is either vinylene(--CH.dbd.CH--) or ethylene (--CH.sub.2 --CH.sub.2 --) when it is bound to two sulfur atoms in a cyclic form or represents two methyl groups separately bound to each sulfur atom.

REFERENCES:
patent: 4533502 (1985-08-01), Rochon et al.
patent: 4560782 (1985-12-01), Papageorgion et al.
patent: 4565884 (1986-01-01), Andrulis, Jr. et al.
patent: 4730069 (1988-03-01), Kolar et al.
patent: 4797393 (1989-01-01), Farrell et al.

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