Anti-tumor halo bicyclo alkanones

Details Anti-tumor halo bicyclo alkanones Anti-tumor halo bicyclo alkanones

1986-03-12

1987-08-25

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ketone doai

514530, 560119, 568374, A61K 3112, C07C 6974

Patent

active

046893490

ABSTRACT:
Potent tumor inhibitors are prepared which are compounds of the formula: ##STR1## wherein Q is CO, CH(OH) or C(OH)CH.sub.3,

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patent: 4322435 (1982-03-01), Kojima et al.
Ford et al., "Anti-Neoplastic Effects of Metcyclor," 14th International Congress of Chemotherapy, Kyoto, Japan, Jun. 1985.
Ford et al., "Modulation of Connective Tissue Metabolism by Steroid Hormones and Ethocyn," 14th International Congress of Chemotherapy, Kyoto, Japan, Jun. 1985.
King et al., "Effects of Cyoctol vs. 13-Cis Retinoic Acid on Dihydrotestosterone Receptor Binding in Human Facial Sebacious Glands," 14th International Congress of Chemotherapy, Kyoto, Japan, Jun. 1985.
Ford et al., "Dense Intraabdominal Adhesions-A Manifestation of Localized Hyper-Androgen Receptors," 14th International Congress of Chemotherapy, Kyoto, Japan, Jun. 1985.
Ford et al., "Differential Androgen Receptor Activity in Patients with Androgenic alopecia and the Effects of Cyoctol on Dihydrotestosterone (DHT) Protein Binding" 14th International Congress of Chemotherapy, Kyoto, Japan, Jun. 1985.
King et al., "Effects of Cyoctol vs. 13-Cis Retinoic Acid on Dihydrotestosterone (DHT) Receptor Binding in Human Facial Skin Fibroblasts," 14th International Congress of Chemotherapy, Kyoto, Japan, Jun. 1985.
Hammill et al., "Effects of Cyoctol on the Hormonally Stimulated Increases in DNA and RNA Metabolism in Fungi" 14th International Congress of Chemotherapy, Kyoto, Japan, Jun. 1985.
Hammill et al., "Dihydrotestosterone and Estradiol Receptors in Trichomonas Vaginalis and the Effects of Cyoctol" 14th International Congress of Chemotherapy, Kyoto, Japan, Jun. 1985.
King et al., "Increased Androgen Binding in Keloids and its Inhibition with Cyoctol" 14th International Congress of Chemotherapy, Kyoto, Japan, Jun. 1985.
Selim et al., "Absorption, Tissue Distribution, Blood Level and Excretion of .sup.14 C Labeled Cyoctol Following Oral or Dermal Administration", Abstract presented at 6th CIRD Symposium, Cannes, France, Oct. 1985.

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