Anti-tumor DC-52 derivatives

Details Anti-tumor DC-52 derivatives Anti-tumor DC-52 derivatives

1989-08-30

1990-08-07

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D471180, C07D49822, A61K 31495

Patent

active

049469576

ABSTRACT:
The present invention relates to novel derivatives of DC-52 represented by the following formula (I): ##STR1## [wherein X is chlorine, bromine, iodine, hydroxyl, formyl, hydroxyiminomethyl, cyano, nitro, amino or lower alkanoylamino; and Y is hydroxyl and Z is cyano, or Y and Z represent --O-- in the form of --Y--Z--]. These compounds and pharmacologically acceptable salts thereof have high anti-tumor activity.

REFERENCES:
patent: 4650869 (1987-03-01), Hirata et al.

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