Anti-tumor compounds, pharmaceutical compositions, methods for p

Details Anti-tumor compounds, pharmaceutical compositions, methods for p Anti-tumor compounds, pharmaceutical compositions, methods for p

1995-10-13

1998-01-06

Owens, Amelia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514337, 514422, 514444, 514449, 549 60, 549214, 549473, 549510, 549511, 548525, 546196, 546269, A61K 31445, C07D30500

Patent

active

057055084

ABSTRACT:
The present invention is directed to novel taxanes useful as chemotherapeutic agents or their precursors. Processes for preparing the novel taxanes include coupling reactions, in the presence of a base, of baccatin of formula (III) or (IV) ##STR1## with .beta.-lactams of formula (V). ##STR2## The invention also provides pharmaceutical compositions including the novel taxanes and methods for treatment of certain cancers with these new compounds.

REFERENCES:
patent: 4876399 (1989-10-01), Holton et al.
patent: 4924012 (1990-05-01), Colin et al.
patent: 4960790 (1990-10-01), Stella et al.
patent: 5015744 (1991-05-01), Holton
patent: 5175315 (1992-12-01), Holton
patent: 5264591 (1993-11-01), Bombardelli et al.
patent: 5475011 (1995-12-01), Ojima et al.
Appendino et al., "14.beta.-Hydroxy-10-deacetylbaccatin III, a New Taxane from Himalayan Yew (Taxus wallichiana Zucc.)", J. Chem. Soc., Perkin Trans, 1, 2925-2529 (1992).
Ojima et al., "New and Efficient Approaches to the Semisynthesis of Taxol and Its C-13 Side Chain Analogs by Means of .beta.-Lactam Synthon Method", Tetrahedron, 48, 6985-7012 (1992).
Commercon et al., "Improved Protection and Esterification of a Precursor of the Taxotere.RTM. and Taxol Side Chains", Tetrahedron Lett., 33, 5185-5188 (1992).
Denis et al., "A Highly Efficient, Practical Approach to Natural Taxol", J. Am. Chem. Soc., 110, 5917-5919 (1988).
Mangatal et al., "Application of the Vicinal Hydroxyanimation Reaction with Asymmetric Induction to the Hemisynthesis of Taxol and Analogs", Tetrahedron, 45, 4177-90 (1989).
Kingston, "The Chemistry of Taxol", Pharmac. Ther., 52, 1-34 (1991).
McLaughlin et al., "19-Hydroxybaccatin III, 1-deacetylcephalomannine, and 10-deacetyltaxol: new antitumor taxanes from Taxus wallichiana", J. Nat. Prod., 44, 312-319 (1981).
Riondel et al., "Antineoplastic Activity of Two Taxol Derivatives on an Ovarian Tumor Xenograted Into Nude Mice", Anticancer Res., 8, 387-390 (1988).
Gueritte-Voegelein et al., "Relationships between the Structure of Taxol Analogues and their Antimitotic Activity", J. Med. Chem., 34, 992 (1991).
Swindell et al.,, "Biologically Active Taxol Analogues with Deleted A-ring Side Chain Substituents and Variable C-2' Configurations", J. Med. Chem., 34, 1176-1184 (1991).
Georg et al., "Taxol Photoaffinity Label: 7-(p-Azidobenzoyl)taxol Synthesis and Biological Evaluation", BioMed. Chem. Lett., 2, 735-738 (1992).
Georg et al., "Synthesis of Biologically Active Taxol Analogues with Modified Phenylisoserine Side Chains", J. Med. Chem., 35, 4230-4237 (1992).
Georg et al., "Semisynthesis and Biological Activity of Taxol Analogues: Baccatin III 13-(N-benzoyl)-(2'R,3'S)-3'-(p-tolyl)isoserinate), Baccatin III 13-(N-toluoyl-(2'R,3'S)-3'-phenylisoserenate), Baccatin III 13-(N-benzoyl-(2'R,3'S)-3'-)p-trifluoromethylphenyl)isoserinate), and Baccatin III 13-(N-(p-trifluoromethylbenzoyl-(2'R,3'S)-3'-phenylisoserinate", BioMed. Chem. Lett., 2, 1751-1754 (1992).
Matthew et al., "Synthesis and Evaluation of Some Water-Soluble Produrgs and Derivatives of Taxol with Antitumor Activity", J. Med. Chem., 35, 145-151 (1992).
Ojima, I., "Synthesis of New Antitumor Taxoids", Abstract No. 347 of Oral Presentation Given at 207th American Chemical Society National Meeting, American Chemical Society Division of Medicinal Chemistry, (Mar. 13-17, 1994).
Fenoglio, I., et al., "Synthesis and SAR Study of New Taxoids from 14-.beta.-OH-10-Deacetyl Baccatin III", Abstract No. 85 of Oral Presentation Given at 207th American Chemical Society National Meeting, American Chemical Society Division of Medicinal Chemistry, (Mar. 13-17, 1994).

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