Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-03-26
1995-12-12
Ivy, Warren C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514337, 514422, 514444, 514449, 549 60, 549473, 549510, 549214, 548525, 546196, 546269, A61K 31445, C07D30500
Patent
active
054750113
ABSTRACT:
The present invention is directed to novel taxanes useful as chemotherapeutic agents or their precursors. Processes for preparing the novel taxanes include coupling reactions, in the presence of a base, of baccatin of formula (III) or (IV) ##STR1## with .beta.-lactams of formula (V). ##STR2## The invention also provides pharmaceutical compositions including the novel taxanes and method for treatment of certain cancers with these new compounds.
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Bombardelli Ezio
Ojima Iwao
Ivy Warren C.
Owens A. A.
The Research Foundation of State University of New York
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