Anti-tumor compounds, pharmaceutical compositions, methods for p

Details Anti-tumor compounds, pharmaceutical compositions, methods for p Anti-tumor compounds, pharmaceutical compositions, methods for p

1995-06-05

1997-02-04

Owens, Amelia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544131, 544144, 544146, 544147, 544148, 544149, 544152, 514337, 514422, 514444, 514449, 549 60, 549214, 549473, 549510, 546196, 546 14, 546256, 546194, 5462784, 5462804, 5462817, 5462821, 5462844, 5462791, 5462681, 5462847, 5462764, 5462834, 5462824, 5462837, 548525, A61K 31445, A61K 3121

Patent

active

055998208

ABSTRACT:
The present invention is directed to novel taxanes useful as chemotherapeutic agents or their precursors. Processes for preparing the novel taxanes include coupling reactions, in the presence of a base, of baccatin of formula (III) or (IV) ##STR1## with .beta.-lactams of formula (V). ##STR2## The invention also provides pharmaceutical compositions including the novel taxanes and methods for treatment of certain cancers with these new compounds.

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