Anti-tumor compositions containing the reactive product of benza

Details Anti-tumor compositions containing the reactive product of benza Anti-tumor compositions containing the reactive product of benza

1986-02-26

1992-12-08

Higel, Floyd D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548201, A61K 31425

Patent

active

051698587

ABSTRACT:
A composition for therapy of tumors having high tyrosinase activity contains the reaction product of penicillamine with a cytotoxic aldehyde, or pharmaceutically acceptable salts or esters thereof, and a pharmaceutically acceptable vehicle. The preferred compounds are 5,5-dimethyl-2-phenyl-4-thiazolidine carboxylic acid or 5,5-dimethyl-2-(2-hydroxyphenyl)-4-thiazolidine carboxylic acid, or pharmaceutically acceptable salts or esters thereof. Treatment preferably comprises an intra-arterial drip. Diagnosis of tumors suitable for treatment by means of these compositions may be accomplished by administering a radioactive copper salt and scanning for accumulations of radioactivity. This will indicate sites of high tyrosinase activity.

REFERENCES:
patent: 4384001 (1983-05-01), Gosalvez
Brugarolas, A. et al., "Treatment of Cancer by an Inducer of Reverse Transformation," Lancet 1980, 1 (8159), 68-70; (Chem. Abstract No. 92:157869n).
Terol, A. et al., Eur. J. Med. Chem.-Chimica Therapeutica, 13, 2, 149-151 (1978).
Oehler, E. et al., Chem. Ber. 112, 107-115 (1979).
Paul, B. et al., Journal of Medicinal Chemistry, 1976, vol. 19, No. 8, 1002-1007.

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