Anti-tumor agent

Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Oxidoreductases

Reexamination Certificate

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Details

C424S094300, C435S189000, C435S188000

Reexamination Certificate

active

07150870

ABSTRACT:
The invention prevents or treats a tumor, inhibiting tumor growth and malignant progression by providing an antitumor agent containing a treated SOD as the active ingredient, especially a melon SOD coated with gliadin. The invention also applies to a method of preventing or treating the tumor.

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van Rossen et al., “Scavenging of reactive oxygen species leads to diminished peritoneal tumor recurrence,” J Cancer Res 60:5625-5629, 2000.
Das et al., “Inhibition of tumor growth and inflammation by consumption of tea,” Phytother Res 16 (Suppl 1):S40-44, Mar. 26, 2002.
Gorman et al., “The hope and the hype,” Time 151(19):40-44, 1998, see also enclosed HTML copy, reference pp. 1-9.
Gura, “Systems for identifying new drugs are often faulty,” Science 278:1041-1042, 1997.
Oxidants, antioxidants, and the degenerative diseases of aging by Bruce Ames et al,Proc. Natl. Acad. Sci. USA, vol. 90, pp. 7915-7922, Sep. 1993.
Malignant progression of a mouse fibrosarcoma by host cells reactive to a foreign body (gelatin sponge) , by F. Okada et al,Br. J. Cancer, (1992), 66, 635-639.

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