Anti-trypanosomal activity of platinum co-ordination compounds

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424131, A61K 3324

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active

045321221

ABSTRACT:
A novel method has been developed for improved chemotherapy of animals infected with African trypanosomiasis. The method involves the concurrent administration of therapeutically effective amounts of cis-diamminedichloroplatinum (II) and bis-(diethylthiocarbamoyl)disulfide (disulfiram) or diethyl dithiocarbamate to the hydrated animal.

REFERENCES:
Borch et al., Proc. Natl. Acad. Sci., USA, vol. 76, No. 12, pp. 6611-6614, Dec. 1979).
Kinnamon et al., Antimicrobial Agents and Chemotherapy, Feb. 1979, pp. 157-160.

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