Anti Thy 1.2 monoclonal antibody-ricin hybrid utilized as a tumo

Details Anti Thy 1.2 monoclonal antibody-ricin hybrid utilized as a tumo Anti Thy 1.2 monoclonal antibody-ricin hybrid utilized as a tumo

1980-09-30

1982-11-16

Fagelson, Anna P.

Drug, bio-affecting and body treating compositions

Lymphokine

260112R, 260121, 424 12, 424 88, 424101, 424177, A61K 3944, A61K 4505, G01N 3368

Patent

active

043594573

ABSTRACT:
A tumor suppressive composition active against lymphoma consisting of an injection of hybrid protein anti Thy 1.2 monoclonal antibody-ricin and hyperosmotic lactose. The inoculation i.v. of murine tissues in vivo by lymphoma is made at -20 to -25 days and the tumor suppressant composition is used i.v. at Day 1 in an amount of 1-3 .mu.g of anti Thy monoclonal antibody-ricin together with sufficient hyperosmotic lactose to raise the lactose level to 20-30 mM. The broad purpose of this invention is to modify the receptor specificity of a potent toxin such as ricin by coupling it with a monoclonal antibody directed at a specific tumor or differentiation antigen. The object here is to use the reagent to selectively kill tumor cells without affecting normal cells.

REFERENCES:
Neville, et al. Biochemical Soc., London, Transactions, vol. 8 No. 6, 1980 pp. 692-693.
Moolten et al., Proc. Amer. Asso. for Cancer Res., Abstracts, vol. 15 1974, p. 24, Ab. No. 94.
Jansen et al., Immunobiology, vol. 157, No. 3, 1980 pp. 229-230.
Youle et al., Proc. Natl. Acad. Sci., vol. 77, No. 9, Sep., 1980 pp. 5483-5486.
Saxena et al., Immunological Communications, vol. 9, No. 4, 1980 pp. 371-378.
Youle et al., Proc. Natl. Acad. Sci., USA, vol. 76, 1979 pp. 5559-5562.

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