Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1989-10-10
1991-09-24
Lee, Lester L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 19, 530331, A61K 6700
Patent
active
050514059
ABSTRACT:
Disclosed are novel peptides and pseudopeptides and pharmaceutical compositions thereof containing certain amino acids and pharmaceutical compositions thereof that inhibit platelet aggregation and thrombus formation in mammalian blood.
REFERENCES:
patent: 4683291 (1987-07-01), Zimmerman et al.
Pierschbacher, J. Biol. Chem., "Influence of Stereochemistry of the Sequence . . . ", pp. 17294-17298 (1987).
"Competition for Related by Nonidentical Binding Sites on the Glycoprotein IIb-IIIa Complex by Peptides Derived from Platelet Adhesive Proteins", Cell, vol. 48 (Mar.) 1987, pp. 867-873; Santoro et al.
"Inhibition of Platelet Adhesion to Fibronectin, Fibrinogen and von Willebrand Factor Substrates by a Synthetic Tetrapeptide Derived from the Cell-Binding Domain of Fibronectin", Blood, vol. 66, No. 4 (Oct.), 1985, pp. 946-952, Haverstick et al.
"Inhibition of Fibrinogen Binding to Human Platelets by the Tetrapeptide Glycyl-L-Prolyl-L-Arginyl-L-Proline", Plow et al., Proc. Natl. Acad. Sci., vol. 79 (Jun.) 1982, pp. 3711-3715.
"The Effect of Arg-Gly-Asp-Containing Peptides on Fibrinogen and von Willebrand Factor Binding to Platelets", Plow et al., Proc. Natl. Acad. Sci., vol. 82 *Dec.) 1985, pp. 8057-8061.
Czekaj Mark
Gardner Charles J.
Klein Scott I.
Molino Bruce F.
Balogh Imre (Jim)
Kraus E. J.
Lee Lester L.
Nicholson James A.
Rhone-Poulenc Rorer Pharmaceuticals Inc.
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