Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1989-09-29
1990-08-28
Lee, Lester L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530330, 530331, A61K 3700
Patent
active
049525620
ABSTRACT:
Disclosed are novel peptides and pseudopeptides and pharmaceutical compositions thereof that inhibit platelet aggregation and thrombus formation in mammalian blood.
REFERENCES:
patent: 4683291 (1987-07-01), Zimmerman et al.
patent: 4857508 (1989-08-01), Adams et al.
"Inhibition of Platelet Adhesion to Fibronecin, Fibrinogen and von Willebrand Factor Substrates by a Synthetic Tetrapeptide Derived from the Cell-Binding Domain of Fibronection", Blood, vol. 66, No. 4 (Oct.), 1985, pp. 946-952, Haverstick et al.
"Inhibition of Fibrinogen Binding to Human Platelets by the Tetrapeptide Glycyl-L-Prolyl-L-Arginyl-L-Proline", Proc. Natl. Acad. Sci. vol. 79, (Jun.) 1982, pp. 3711-3715; Plow et al.
"The Effect of Arg-Gly-Asp-Containing Peptides on Fibrinogen and von Willebrand Factor Binding to Platelets", Proc. Natl. Acad. Sci., vol. 82 (Dec.) 1985, pp. 8057-8061; Plow et al.
"Competition for Related but Nonidentical Binding Sites on the Glycoprotein IIb-IIIa Complex by Peptides Derived from Platelet Adhesive Proteins", Cell, vol. 48, (Mar.) 1987, pp. 867-873, Santoro et al.
Plow et al., "The Effect of Arg-Gly-Asp . . . ", Natl. Acad. Sci. 12/85, pp. 8057-8061.
Czekaj Mark
Gardner Charles J.
Klein Scott I.
Molino Bruce F.
Pelletier Jeffrey C.
Balogh Imre (Jim)
Jervis Herbert H.
Lee Lester L.
Macbius Stephen
Nicholson James A.
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